Tricarboxylic acids and derivatives
Selleck Chemical LLC Citric acid trilithium salt tetrahydrate S4519-100mg
Citric acid trilithium salt tetrahydrate (Trilithium citrate tetrahydrate Lithium citrate tribasic tetrahydrate) is a pharmaceutical and construction material It is commonly used in HPLC gradient elution for quantification of amino acids
Medchemexpress LLC Gefapixant citrate | 2310299-91-1 | 99.2% | 545.5 g/mol | C20H27N5O11S | 1 ML
Gefapixant citrate is a P2X3 receptor antagonist provided as a concentrated solution for laboratory research. The reagent is supplied at 10 mM in DMSO (1 mL) and is intended for in vitro pharmacology and biochemical studies, with analytical documentation available from the manufacturer.
- Ready-to-use 10 mM solution in DMSO, 1 mL.
- High purity (99.2%) suitable for research applications.
- Supports in vitro P2X3 receptor pharmacology and biochemical assays.
- Comes with data sheet, certificate of analysis, and safety data sheet.
- For research use only; not for human or diagnostic use.
eMolecules 1258947-79-3 | Tris(4-(1H-imidazol-1-yl)phenyl)amine | ChemScene443.514 | C27H21N7 | 95.000 | c1cn(cn1)-c1ccc(cc1)N(c1ccc(cc1)-n1ccnc1)c1ccc(cc1)-n1ccnc1 | 250mg | 582646168
Tris(4-(1H-imidazol-1-yl)phenyl)amine | ChemScene | 1258947-79-3443.514 | C27H21N7 | 95.000 | c1cn(cn1)-c1ccc(cc1)N(c1ccc(cc1)-n1ccnc1)c1ccc(cc1)-n1ccnc1 | 250mg | 582646168
TARGETMOL CHEMICALS INC Zoledronic acid monohydrate
Also available in 10 mg, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity. Purity ≥95%
Medchemexpress LLC Ferric citrate | 3522-50-7 | 244.94 | 100 MG
Ferric citrate (Iron(III) citrate) is an orally active iron supplement and an efficacious phosphate binder. It is used for research related to iron deficiency anemia and chronic kidney disease (CKD).
- Orally active iron supplement.
- Efficacious phosphate binder.
- Can be used for iron deficiency anemia and chronic kidney disease (CKD) research.
- Reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease.
- Increases iron stores and reduces intravenous iron and erythropoietin-stimulating agent use while maintaining hemoglobin.
- Can increase transferrin saturation, serum ferritin, and hemoglobin.
Medchemexpress LLC Citrate synthase | 9027-96-7 | ~98 KDa dimer (49 KDa monomer) | 500 U
Citrate synthase catalyzes the initial reaction of the citric acid cycle, condensing acetyl-CoA and oxaloacetate to form citrate. This enzyme is primarily localized within the mitochondrial matrix of eukaryotic cells. Each unit of the enzyme is defined by its ability to form 1.0 μmole of citrate from oxalacetate and acetyl CoA per minute at pH 8.0 at 37°C.
- Catalyzes key reaction in citric acid cycle
- Localized in mitochondrial matrix
- Biochemical reagent
- Metabolic enzyme/protease
- Endogenous metabolite
Medchemexpress LLC 2-methylcitric acid trisodium | 117041-96-0 | MFCD16875437 | 96.0% | 272.10 g·mol⁻1 | C7H7Na3O7 | 5 MG
2-Methylcitric acid trisodium is the trisodium salt of 2-methylcitric acid provided as a white to off-white solid for laboratory research. It is an endogenous metabolite used as a marker in methylmalonic and propionic acidemias and is employed in biochemical and mitochondrial studies, where it has been reported to inhibit ADP-stimulated mitochondrial respiration supported by glutamate.
- Trisodium salt, white to off-white solid.
- CAS number 117041-96-0.
- Purity 96.0%.
- Molecular weight 272.10 g·mol⁻1; formula C7H7Na3O7.
- Highly soluble in water (100 mg/mL; may require ultrasonication).
- Storage: sealed at 4°C; in solvent -80°C (6 months), -20°C (1 month).
- For research use only; not for human or veterinary use.
Medchemexpress LLC cGAMP diammonium | 96.6% | 708.47 | 50 MG
cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
- Endogenous second messenger in metazoans.
- Triggers interferon production in response to cytosolic DNA.
- Activates stimulator of interferon genes (STING).
- Activates a signaling cascade leading to the production of type I interferons and other immune mediators.
- Promotes the antigen-specific proliferation capacity of spleen cells in mice.
- Directly activates murine and human dendritic cells *in vitro*.
Apexbio Technology LLC Clomiphene citrate 50-41-9 10mM (in 1mL DMSO)
Clomiphene citrate (CAS 50-41-9) is a small-molecule modulator targeting estrogen receptors (ER) It is designed to selectively modulate ER-mediated signaling thereby influencing estrogen-dependent cellular pathways Clomiphene citrate exerts its biological activity primarily through competitive inhibition at estrogen receptors It demonstrates both antiestrogenic and estrogenic activities depending on tissue context Based on these pharmacological properties clomiphene citrate holds research potential in the investigation of estrogen receptor-mediated transcriptional regulation cellular proliferation and differentiation as well as hypothalamic-pituitary-gonadal axis regulation and ovarian follicular maturation in reproductive biology studies
Medchemexpress LLC Bromo-PEG1-CH2COOH | 1135131-50-8 | >=97.0% | 100 MG
Bromo-PEG1-CH2COOH is a PROTAC linker, designed for use in the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, by connecting an E3 ubiquitin ligase ligand to a target protein ligand.
- Used as a PROTAC linker
- Designed for PROTAC synthesis
- Contains two ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase
- Other ligand targets a protein
- Exploits the ubiquitin-proteasome system
- Enables selective degradation of target proteins
- For research use only
Medchemexpress LLC SPD-473 citrate | 161190-26-7 | MFCD31382144 | 99.8% | 552.47 g/mol | C23H31Cl2NO8S | 1 MG
SPD-473 citrate is the citrate salt of a triple reuptake inhibitor that blocks serotonin, dopamine, and norepinephrine transporters. Supplied for research use, it is a characterized white to off-white solid with documented purity and solubility data for in vitro and in vivo studies.
- Acts as a serotonin, dopamine, and norepinephrine reuptake inhibitor.
- High purity (99.8%).
- Molecular weight 552.47 g/mol.
- White to off-white solid suitable for laboratory handling.
- High solubility in DMSO (100 mg/mL); in vivo formulation protocols provided.
- Available in 1 mg, 5 mg, 10 mg, and 25 mg pack sizes for screening and pilot studies.
Medchemexpress LLC 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester | 544450-68-2 | 99.94% | 337.82 | 100 MG
COR659 is a potent and effective GABAB positive allosteric modulator (PAM) that suppresses alcohol and chocolate self-administration in rats. Its effects are exerted through a composite mechanism, involving positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.
- Potent and effective GABAB positive allosteric modulator (PAM).
- Suppresses alcohol and chocolate self-administration in rats.
- Exerts effects through a composite mechanism.
- Involves positive allosteric modulation of the GABAB receptor.
- Acts at the cannabinoid CB1 receptor.
- Has shown cytotoxicity against mouse NIH/3T3 cells with an IC50 of 59 μM.
- Relevant to research in neurological, eye or ear disease, neurodegenerative disease, depression, Alzheimer's disease, and Parkinson's disease.
Medchemexpress LLC Azido-PEG2-CH2COOH | 882518-90-3 | 99.0% | 189.17 | 250 MG
Azido-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules possessing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when combined with molecules containing DBCO or BCN groups.
- PROTAC linker for PROTAC synthesis
- Click chemistry reagent
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
eMolecules 23142-01-0 | Pentoxyverine citrate | MFCD00055697 | 1g
Ambeed | rel-(3R4S5S6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2345-tetraol | 1g | 649269182 | A1497324 | 54-17-1 | MFCD00063684 | 180.156 | C6H12O6
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Medchemexpress LLC Cyclic GMP-AMP diammonium | 96.6% | 708.47 g/mol | C20H30N12O13P2 | 5 MG
cGAMP diammonium is a cyclic dinucleotide that functions as an endogenous second messenger and a potent activator of the stimulator of interferon genes (STING) pathway. Provided as the diammonium salt for research use, it induces type I interferon production and is used to study innate immune signaling.
- Activates STING and triggers type I interferon signaling.
- High purity (96.6%) suitable for research applications.
- Molecular formula C20H30N12O13P2; molecular weight 708.47 g/mol.
- Water-soluble; dissolves up to 100 mg/mL with ultrasonic assistance.
- Solid storage recommended at -20°C; solution storage guidance provided.
- Supplied in small quantities (e.g., 5 mg) for laboratory use.