Tricarboxylic acids and derivatives
Medchemexpress LLC m-PEG8-CH2COOH | 102013-72-9 | 99.9% | 100 MG
m-PEG8-CH2COOH is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. These compounds operate by exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based linker
- Used in the synthesis of PROTACs
- Selectively degrades target proteins
- Molecular weight: 442.50
- Formula: C19H38O11
- Appearance: Liquid
- Color: Colorless to light yellow
- Soluble in DMSO (200 mg/mL)
Medchemexpress LLC (E/Z)-Zotiraciclib hydrochloride | 1321626-25-8 | C23H25ClN4O | 5 MG
(E/Z)-Zotiraciclib ((E/Z)-TG02) is an orally active inhibitor of CDK2, JAK2, and FLT3 with IC50s of 13, 73, and 56 nM, respectively. It effectively inhibits the proliferation of cancer cells, making it suitable for cancer research.
- Orally active inhibitor of CDK2, JAK2, and FLT3
- Inhibits proliferation of cancer cells
- Useful for cancer research
- Potently inhibits the CDK2 biomarker pRb
Medchemexpress LLC m-PEG10-CH2COOH | 908258-58-2 | ≥98.0% | 530.60 | 1 G
m-PEG10-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting two different ligands, one for an E3 ubiquitin ligase and the other for the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Contains two different ligands connected by a linker
- One ligand for E3 ubiquitin ligase, the other for target protein
Medchemexpress LLC Mangafodipir trisodium | 140678-14-4 | 99.7% | 5 MG
Mangafodipir trisodium (MnDPDP) is a hepatocellular-specific contrast agent and an efficacious inhibitor of chemotherapy-induced peripheral neuropathy (CIPN) and other conditions caused by cellular oxidative stress. It shows no negative interference with the tumoricidal activity of chemotherapy.
- Hepatocellular-specific contrast agent
- Efficacious inhibitor of chemotherapy-induced peripheral neuropathy
- Attenuates apoptosis caused by cisplatin in HGrC cells
- Protects against ovarian damage caused by cisplatin and paclitaxel in mice
Medchemexpress LLC Oxolamine citrate (SKF-9976 citrate) | 1949-20-8 | 99.9% | 1 ML
Oxolamine citrate (SKF-9976 citrate) is an orally active antitussive that can inhibit CYP2B1/2 and has anti-inflammatory effects on the respiratory organs of guinea pigs. It increases the AUC of Warfarin and prolongs its terminal half-life. It can be used in respiratory disease research.
- Orally active antitussive
- Inhibits CYP2B1/2
- Has anti-inflammatory effects on the respiratory organs of guinea pigs
- Increases the AUC of Warfarin and prolongs its terminal half-life
- Can be used in respiratory disease research
Medchemexpress LLC Tos-PEG3-CH2COOH | 1581248-63-6 | 50 MG
Tos-PEG3-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTACs feature two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other binds to a specific target protein. This mechanism allows PROTACs to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Leverages ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Icerguastat (Sephin1) | 951441-04-6 | 99.93% | 196.64 | 10 MG
Icerguastat (Sephin1) is a Guanabenz derivative that selectively inhibits the phosphatase regulatory subunit PPP1R15A (R15A). It functions by inhibiting eIF2α dephosphorylation, which prolongs the protective cellular response and demonstrates an anti-prion effect.
- Selectively inhibits the phosphatase regulatory subunit PPP1R15A (R15A).
- Inhibits eIF2α dephosphorylation, extending protective cellular responses.
- Demonstrates anti-prion effects in models.
- Prolongs eIF2α phosphorylation in stressed oligodendrocytes.
- Delays the onset of experimental autoimmune encephalomyelitis (EAE) in animal models.
- Prolongs survival in prion-infected mice.
Medchemexpress LLC (E/Z)-Zotiraciclib citrate | 1204918-73-9 | C29H32N4O8 | 100 MG
(E/Z)-Zotiraciclib citrate is a potent inhibitor targeting CDK2, JAK2, and FLT3. It is intended for research use only.
- Potent CDK2, JAK2, and FLT3 inhibitor
- Purity: 99.83%
- Molecular weight: 564.59
- Chemical formula: C29H32N4O8
- CAS number: 1204918-73-9
- Appearance: Solid, off-white to light yellow
- Solubility in DMSO: 250 mg/mL
Medchemexpress LLC Azido-PEG6-CH2COOH | 880129-82-8 | ≥98.0% | 365.38 | 5 G
Azido-PEG6-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Suitable for synthesizing PROTACs
- Click chemistry reagent due to azide group
- Enables CuAAc reactions
- Participates in SPAAC reactions with DBCO or BCN groups